Clinical Trials Exploring Cannabis on Anxiety Disorders
This review of ongoing and completed clinical trials notes many small-scale studies and case reports suggesting CBD’s anxiolytic potential.
Cannabidiol on Worry and Anxiety
A study found that CBD did not reduce worry but did show some effect on physical symptoms of anxiety.
Anxiety Patients Treated with Cannabis
Study of patients with generalized anxiety disorder (GAD) treated with cannabis.
Cannabidiol Usage, Efficacy, and Side Effects
A 2024 review summarizing human and animal studies of CBD for anxiety and sleep.
Medicinal Cannabis in the Management of Anxiety Disorders
A 2025-published review suggests that cannabis may have therapeutic potential for anxiety disorders.
Antidepressant and Anxiolytic Effects of Cannabis
This study found that initiation of cannabis was associated with significant decreases in anxiety and depression symptoms in clinically anxious and depressed populations.
The Evolving Role of Cannabis in People with Autism
Review of recent human studies using CBD-rich cannabis in children and adults with ASD.
Efficacy and Safety of Cannabinoids for Autism
Updated review of clinical and observational studies (353+ participants) concluded that CBD-rich formulations show promise for managing irritability, hyperactivity, anxiety, and sleep problems in ASD.
Cannabis Use in Autism Spectrum Disorder
Across multiple small studies, over 80% of parents in some cohorts reported global improvement (behavior, sleep, anxiety), but designs were uncontrolled and heterogeneous.
Efficacy and Safety of Cannabis in Children with Autism
CBD extract improved social interaction and several co-existing features versus placebo, with only mild adverse effects in a minority of children.
Children and Adolescents Treated with Cannabis Exhibit Improvements in Social Symptoms
SRS showed improvements in social communication and some restricted/repetitive behaviors in youths with ASD treated with CBD-rich cannabis; treatment was generally well tolerated.
Cannabis for Autism Spectrum Disorder
33 children with ASD received CBD-enriched full-spectrum cannabis for 6 months. Parents reported reduced behavioral problems and improved expressive language.
Effects of Cannabis on Autism
Compassionate-use study from Brazil: CBD led to amelioration of multiple ASD symptoms in most participants, with some able to reduce other psychotropic medications.
Real Life Experience of Cannabis Treatment in Autism
Large real-world cohort treated with CBD-rich cannabis. After 6 months, over 80% of assessed patients showed at least moderate improvement in overall condition.
Cannabis and Cannabinoids in Adults With Cancer
Review of evidence that cannabis and/or cannabinoids may improve refractory chemotherapy-induced nausea and vomiting when added to guideline anti-emetic therapy.
Indications of Cannabinoids for the Palliation of Cancer‐Associated Symptoms
Found modest reductions in and anxiety, improvements in appetite, chemotherapy-induced nausea/vomiting (CINV) and insomnia.
Medical Cannabis Outcomes and Cancer: Symptom Management in Oncology
Large study reported 70-90% of cancer patients using cannabis reported symptom improvement (pain, nausea, appetite) with <5% adverse events.
Evidence Supporting Medicinal Cannabis as Analgesic in Cancer Patients
Review of studies in cancer pain showing analgesic potential of cannabis/cannabinoids.
Cannabis for Chronic Pain
Followed 218 adult patients with chronic pain treated with individually-titrated cannabis oil extracts over 6 months. Pain scores dropped from 7.9 to 6.6.
Cannabis Use Among Patients with Chronic Pain
Cannabis-exposed patients had fewer urgent care visits and ED visits and fewer unhealthy days per month.
Cannabis versus Opioids for Chronic Pain
Review of cannabis vs opioids in non-cancer chronic pain. Found that cannabis may be similarly effective to opioids for physical functioning and had fewer adverse events.
Cannabis for the Management of Chronic Pain
Based on a living systematic review, the guideline states select individuals with chronic neuropathic pain may experience small short-term pain improvements with high THC-to-CBD cannabis products.
Cannabinoids in Chronic Pain Management
Review article noting that recent studies reaffirm analgesic + anti-inflammatory properties of THC and CBD, especially in neuropathic pain.
Medicinal Cannabis for Pain
Real-world study of chronic non-malignant pain patients treated with cannabis. Found reductions in pain severity and interference and improvements in quality of life after 3 months.
Cannabis Compared to Opioids on Pain Relief
Study from the UK comparing cannabis vs opioids for chronic pain found evidence that THC-predominant cannabis may reduce the unpleasantness of pain via brain connectivity changes.
Cannabis for Chronic Pain
Website summarizing evidence: cannabis holds promise for some subgroups for short-term relief; heterogeneity of studies and formulations limits generalizability.
Cannabis Products for Chronic Pain
Meta-analysis found moderate improvement in pain severity with high THC-to-CBD products.
CBD for Adult Patients with Drug-Resistant Epilepsy
Study in adults with drug-resistant epilepsy (DRE) using CBD-enriched oil showed that a subset of patients achieved meaningful seizure reduction.
The Effect of CBD on Seizure Features and Quality of Life
Randomized controlled trial in patients with epilepsy comparing CBD vs placebo for 8 weeks. CBD group had a mean reduction in seizure frequency (~45.6 seizures vs ~9 in placebo) at 8 weeks and improved quality of life.
The Efficacy and Safety of CBD in Pediatric Patients with Epilepsy
CBD treatment in children with major motor seizures led to a 50% reduction in median monthly major motor seizures and 44% reduction in total seizures after 12 weeks.
Is a Low Dosage of Medical Cannabis Effective for Treating Fibromyalgia?
In a cohort of FM patients, pain intensity dropped from a median of 8/10 at baseline to 4/10 after six months of low-dose medical cannabis. Quality of life measures also improved.
Effectiveness and Safety of Cannabis-based Products for Fibromyalgia
Real-world observational data suggest that medical cannabis use in fibromyalgia is generally safe and associated with symptom improvement (pain relief, reduced medication use, improved sleep).
The Use of Cannabis in the Treatment of Fibromyalgia
An integrative review of studies published 2020-2024 found a predominance of research showing symptom improvement (pain, sleep, mood) in FM patients treated with cannabis and cannabinoids.
Medical Cannabis for the Treatment of Migraine in Adults
Review of 9 human studies (~1,980 participants). Medical cannabis reduced monthly migraine days and was rated more effective than non-cannabis treatments for attack relief.
Efficacy and Safety of Medical Marijuana in Migraine Headache
Review of 9 studies. Concluded that medical cannabis shows a “significant clinical response” for many patients by reducing length and frequency of migraines; no serious adverse events were reported.
Alleviative Effects of Cannabis Flower on Migraine and Headache
People using cannabis flower for migraine/headache reported an average reduction of 3.3 points on a 0–10 pain scale at 2 hours. In some, monthly migraine frequency dropped from 10.4 to 4.6 attacks.
Cannabinoids for Spasticity in Patients with MS
Nabiximols (THC:CBD oromucosal spray) is the most studied agent and produces a modest but statistically significant reduction in spasticity versus placebo.
Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis
Six-month study of 69 MS patients using CBD 13% / THC 9%. Reported reduced muscle spasticity, improved bladder function, and slowing of disability progression.
Cannabinoids for the Treatment of Neuropathic Pain
This review identified 17 trials for neuropathic pain. Ten trials using THC-alone formulations showed the strongest evidence; four using THC/CBD combinations showed some benefit; CBD alone did not show significant effect.
The Use of Cannabinoids in the Treatment of Peripheral Neuropathy
Reviewed 14 RCTs of cannabinoids in peripheral neuropathy. Found that 13 of the 14 observed statistically significant decreases in neuropathic pain scores vs baseline.
Medical Cannabis Alleviates Chronic Neuropathic Pain Effectively
Study of 99 patients with chronic neuropathic pain treated with medical cannabis: Over 40% improvement in pain scores within 6 weeks; benefits sustained; safe and well-tolerated.
The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder
Explores how medicinal cannabis may help in OUD by reducing opioid cravings, easing withdrawal symptoms, and acting as adjuncts to current treatments.
Cannabis as a Facilitator of Decreased Opioid Injection Frequency
Study of people with OUD and chronic pain using medical cannabis for 12 months found that reported reductions in opioid use, improved mood/sleep, and decreased illicit opioid injection frequency.
Cannabis Use and Illicit Opioid Cessation Among People Who Use Opioids
Among people who used illicit opioids, those who reported daily cannabis use had higher hazard rates of opioid cessation than those who did not.
Cannabis for Treating Post-Traumatic Stress Disorder and Comorbid Depression
In a UK registry of patients seeking cannabis-based medicinal products for PTSD after 3 months of treatment there were substantial reductions in PTSD symptom severity.
The Effectiveness of Cannabinoids in the Treatment of PTSD
Review of 10 studies found cannabinoids may reduce PTSD symptoms.
The Impact Cannabis on PTSD Symptoms
In this first RCT of smoked cannabis for PTSD all arms improved significantly.
The Efficacy of Nabilone in the Treatment of PTSD-Associated Nightmares
Canadian military personnel with PTSD nightmares received nabilone or placebo; nabilone significantly reduced frequency/intensity of nightmares.
Medical Cannabis for Treatment-Resistant Combat PTSD
In a follow-up of veterans with treatment-resistant PTSD treated with cannabis, improvements were seen in sleep quality & duration and reductions in PTSD symptoms.
Treating Nightmares in Posttraumatic Stress Disorder
Bedtime oral dronabinol vs placebo in PTSD patients with frequent nightmares.
The Use of Marijuana for Posttraumatic Stress Disorder
Survey among self-reported marijuana users with PTSD found a positive correlation between marijuana use and PTSD symptom severity.
Medicinal Cannabis Improves Sleep in Adults with Insomnia
Randomized, double-blind, placebo-controlled crossover trial in 29 adults with chronic insomnia. Two weeks of active treatment significantly improved total sleep time and sleep quality.
CBN and CBD on Sleep Quality
293 adults with “poor” or “very poor” sleep were randomized for 7 nights. The 20 mg CBN group had significantly fewer nighttime awakenings and reduced overall sleep disturbance vs placebo
THC, CBD and CBN for Sleep Disturbance, Anxiety and Stress
Randomized trial in healthy adults with sleep disturbance. A blend with low concentrations of THC plus CBD and CBN significantly improved sleep disturbance, anxiety, stress and overall well-being.
Cannabidiol in the Management of Insomnia
Systematic review of 34 studies in people with insomnia or sleep complaints. Many reports showed improved sleep onset, maintenance, or overall sleep satisfaction
Using Cannabis to Improve Sleep
Recent trials and observational data on THC, CBD, CBN and other cannabinoids for sleep disorders.
Cannabinoids: Emerging Sleep Modulator
Broad review on how the endocannabinoid system influences sleep–wake regulation and how THC, CBD, and minor cannabinoids affect sleep.
Cannabidiol Improves Sleep
CBD significantly improved perceived sleep quality and enhanced natural-killer cell cytotoxicity (immune function).
CBD for Painful Chronic Osteoarthritis of the Knee
RCT in knee osteoarthritis patients using CBD showed improvement in pain scores compared to placebo.
Transdermal CBD Gel for Symptomatic Hand Osteoarthritis
CBD gel three times daily for 4 weeks led to significant reductions in self-reported pain and improvements in grip strength and certain quality-of-life measures.
Cannabidiol as a Treatment for Arthritis and Joint Pain
Survey of 428 people with arthritis who used CBD. 83% reported improvements in pain; 66% in physical function; 66% in sleep quality. Osteoarthritis group showed greater pain reduction than rheumatoid.
Cannabis for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting
In a trial of 147 evaluable adult cancer patients receiving highly emetogenic chemotherapy, an add-on oral THC:CBD extract improved the complete response rate.
Cannabinoids for the Prevention of Chemotherapy-Induced Nausea and Vomiting
Systematic review of 32 studies of cannabinoid-based therapies for chemo-induced nausea/vomiting. Of the 22 studies, 12 found significant benefit; of nine placebo-controlled, eight found benefit.
Cannabis for Chemotherapy-Induced Nausea and Vomiting
This summary reviews older and recent RCTs of synthetic cannabinoids and cannabis extracts in CINV. It explains that cannabinoids are approved for anti-emetic use when standard therapy fails.